Impact of Respiratory Syncytial Virus Infection on the Host Cell: Implications for Antiviral Strategies.
Identifieur interne : 000430 ( Main/Exploration ); précédent : 000429; suivant : 000431Impact of Respiratory Syncytial Virus Infection on the Host Cell: Implications for Antiviral Strategies.
Auteurs : Mengjie Hu [Australie] ; Marie A. Bogoyevitch [Australie] ; David A. Jans [Australie]Source :
- Physiological reviews [ 1522-1210 ] ; 2020.
Abstract
Respiratory syncytial virus (RSV) is one of the leading causes of viral respiratory tract infection in infants, the elderly and the immunocompromised worldwide, causing more deaths each year than influenza. Years of research into RSV since its discovery over 60 years ago have elucidated detailed mechanisms of the host-pathogen interface. RSV infection elicits widespread transcriptomic and proteomic changes, which both mediate the host innate and adaptive immune responses to infection, and reflect RSV's ability to circumvent the host stress responses, including stress granule formation, endoplasmic reticulum stress, oxidative stress, and programmed cell death. The combination of these events can severely impact on human lungs, resulting in airway remodeling and pathophysiology. The RSV membrane envelope glycoproteins (fusion F and attachment G), matrix (M) and nonstructural (NS) 1 and 2 proteins play key roles in modulating host cell functions to promote the infectious cycle. This review presents a comprehensive overview of how RSV impacts the host response to infection, and how detailed knowledge of the mechanisms thereof can inform the development of new approaches to develop RSV vaccines and therapeutics.
DOI: 10.1152/physrev.00030.2019
PubMed: 32216549
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000128
- to stream PubMed, to step Curation: 000128
- to stream PubMed, to step Checkpoint: 000095
- to stream Ncbi, to step Merge: 000B95
- to stream Ncbi, to step Curation: 000B95
- to stream Ncbi, to step Checkpoint: 000B95
- to stream Main, to step Merge: 000430
- to stream Main, to step Curation: 000430
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of Respiratory Syncytial Virus Infection on the Host Cell: Implications for Antiviral Strategies.</title><author><name sortKey="Hu, Mengjie" sort="Hu, Mengjie" uniqKey="Hu M" first="Mengjie" last="Hu">Mengjie Hu</name><affiliation wicri:level="1"><nlm:affiliation>DBMB, Monash University, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>DBMB, Monash University</wicri:regionArea><wicri:noRegion>Monash University</wicri:noRegion></affiliation></author><author><name sortKey="Bogoyevitch, Marie A" sort="Bogoyevitch, Marie A" uniqKey="Bogoyevitch M" first="Marie A" last="Bogoyevitch">Marie A. Bogoyevitch</name><affiliation wicri:level="4"><nlm:affiliation>DBMB, University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>DBMB, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jans, David A" sort="Jans, David A" uniqKey="Jans D" first="David A" last="Jans">David A. Jans</name><affiliation wicri:level="1"><nlm:affiliation>Dept Biochem. & Mol. Biol., Monash University, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dept Biochem. & Mol. Biol., Monash University</wicri:regionArea><wicri:noRegion>Monash University</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32216549</idno><idno type="pmid">32216549</idno><idno type="doi">10.1152/physrev.00030.2019</idno><idno type="wicri:Area/PubMed/Corpus">000128</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000128</idno><idno type="wicri:Area/PubMed/Curation">000128</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000128</idno><idno type="wicri:Area/PubMed/Checkpoint">000095</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000095</idno><idno type="wicri:Area/Ncbi/Merge">000B95</idno><idno type="wicri:Area/Ncbi/Curation">000B95</idno><idno type="wicri:Area/Ncbi/Checkpoint">000B95</idno><idno type="wicri:Area/Main/Merge">000430</idno><idno type="wicri:Area/Main/Curation">000430</idno><idno type="wicri:Area/Main/Exploration">000430</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of Respiratory Syncytial Virus Infection on the Host Cell: Implications for Antiviral Strategies.</title><author><name sortKey="Hu, Mengjie" sort="Hu, Mengjie" uniqKey="Hu M" first="Mengjie" last="Hu">Mengjie Hu</name><affiliation wicri:level="1"><nlm:affiliation>DBMB, Monash University, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>DBMB, Monash University</wicri:regionArea><wicri:noRegion>Monash University</wicri:noRegion></affiliation></author><author><name sortKey="Bogoyevitch, Marie A" sort="Bogoyevitch, Marie A" uniqKey="Bogoyevitch M" first="Marie A" last="Bogoyevitch">Marie A. Bogoyevitch</name><affiliation wicri:level="4"><nlm:affiliation>DBMB, University of Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>DBMB, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Jans, David A" sort="Jans, David A" uniqKey="Jans D" first="David A" last="Jans">David A. Jans</name><affiliation wicri:level="1"><nlm:affiliation>Dept Biochem. & Mol. Biol., Monash University, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Dept Biochem. & Mol. Biol., Monash University</wicri:regionArea><wicri:noRegion>Monash University</wicri:noRegion></affiliation></author></analytic><series><title level="j">Physiological reviews</title><idno type="eISSN">1522-1210</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Respiratory syncytial virus (RSV) is one of the leading causes of viral respiratory tract infection in infants, the elderly and the immunocompromised worldwide, causing more deaths each year than influenza. Years of research into RSV since its discovery over 60 years ago have elucidated detailed mechanisms of the host-pathogen interface. RSV infection elicits widespread transcriptomic and proteomic changes, which both mediate the host innate and adaptive immune responses to infection, and reflect RSV's ability to circumvent the host stress responses, including stress granule formation, endoplasmic reticulum stress, oxidative stress, and programmed cell death. The combination of these events can severely impact on human lungs, resulting in airway remodeling and pathophysiology. The RSV membrane envelope glycoproteins (fusion F and attachment G), matrix (M) and nonstructural (NS) 1 and 2 proteins play key roles in modulating host cell functions to promote the infectious cycle. This review presents a comprehensive overview of how RSV impacts the host response to infection, and how detailed knowledge of the mechanisms thereof can inform the development of new approaches to develop RSV vaccines and therapeutics.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Hu, Mengjie" sort="Hu, Mengjie" uniqKey="Hu M" first="Mengjie" last="Hu">Mengjie Hu</name></noRegion><name sortKey="Bogoyevitch, Marie A" sort="Bogoyevitch, Marie A" uniqKey="Bogoyevitch M" first="Marie A" last="Bogoyevitch">Marie A. Bogoyevitch</name><name sortKey="Jans, David A" sort="Jans, David A" uniqKey="Jans D" first="David A" last="Jans">David A. Jans</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000430 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000430 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32216549
|texte= Impact of Respiratory Syncytial Virus Infection on the Host Cell: Implications for Antiviral Strategies.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32216549" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |